Research Contents
The laboratory mainly focuses on the design and fabrication of nanofluidic devices for single molecule detection and sensing. (1) Based on micro/nanoscale manufacturing technology, we explored and developed the nanoscale manufacturing principles and processing methods for glass-based, silicon-based, carbon-based, and two-dimensional materials. We have achieved the structural design and fabrication of micro/nanoscale sensors with high precision (less than 2 nm) for single molecule (such as DNA, protein, nanoparticle and virus) detection; (2) Based on all-atom molecular dynamics (MD) simulation, we explored the mechanism of interaction between ions and biomolecules in nanoscale confinements, and we established a mathematical model for the transport of biomolecules in nanochannels, we also studied the transport behavior of single molecules using improved force fields; (3) Based on innovative micro/nanoscale structure design, a single molecule sensing and detection system was constructed, we realized the regulation of molecule transport through nanochannels. We also improved the signal-to-noise ratio of the designed chips, which is significant for maintaining the sensitivity and reliability of sensing and detection of different biological single molecules.
Team members:
Yunfei Chen, Jingjie Sha, Yin Zhang, Wei Si, Haiyan Wang, Jian Ma, Jingwen Mo
